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Dimethyl ether chemical ionization of arylalkylamines
Author(s) -
Ramos Luis E.,
Cardoso Ana M.,
Correia A. J. Ferrer,
Nibbering Nico M. M.
Publication year - 2000
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(20000331)14:6<408::aid-rcm884>3.0.co;2-k
Subject(s) - chemistry , adduct , molecule , chemical ionization , deuterium , dimethyl ether , fragmentation (computing) , ether , medicinal chemistry , amine gas treating , ion , electron ionization , mass spectrometry , ionization , polyatomic ion , stereochemistry , organic chemistry , physics , chromatography , quantum mechanics , methanol , computer science , operating system
The gas‐phase reactions of dimethyl ether (DME) ions with a number of biologically active arylalkylamines of the general formula R 1 R 2 C 6 H 3 CHR 3 (CH 2 ) n NR 4 R 5 , where R 1 = H or OH, R 2 = H, F, NO 2 , OH or OCH 3 , R 3 = H or OH, R 4 and R 5 = H or CH 3 , have been studied by means of chemical ionization mass spectrometry. Under the experimental conditions used, the most abundant DME ion is the methoxymethyl cation (CH 3 OCH 2 + , m/z 45). The unimolecular metastable decompositions of the [M + 45] + , [M + 13] + and [M + 15] + adducts formed have been interpreted in terms of the initial site of reaction with the amines and the presence of different functional groups in the molecule. This has permitted establishment of general fragmentation patterns for the adducts, and their correlation with structural features of the molecules. The main site of reaction of the ion CH 3 OCH 2 + with the amines seems to be the amino group, particularly if the amine is primary, although a competition with attack on the aromatic ring and especially on the benzylic hydroxy group is observed. In a few cases the reaction mechanisms have been elucidated through the use of deuterated amines obtained by H/D exchange with D 2 O. Copyright © 2000 John Wiley & Sons, Ltd.