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Stereochemical differentiation of cyclic glycols by ion‐molecule reactions in a quadrupole mass spectrometer using dimethyl ether acetonitrile and 2‐ S ‐pyrrolidinemethanol
Author(s) -
Mancel Valerie,
Sellier Nicole
Publication year - 2000
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(20000130)14:2<80::aid-rcm838>3.0.co;2-8
Subject(s) - chemistry , acetonitrile , mass spectrometry , triple quadrupole mass spectrometer , ion , molecule , reagent , chemical ionization , ether , diastereomer , quadrupole mass analyzer , stereospecificity , quadrupole ion trap , selected reaction monitoring , ionization , analytical chemistry (journal) , organic chemistry , ion trap , chromatography , tandem mass spectrometry , catalysis
In this study, ion‐molecule reactions using chemical ionization in the positive ion mode using dimethyl ether, acetonitrile and 2‐ S ‐pyrrolidinemethanol as reagent gases have been used to distinguish between cis ‐ and trans ‐1,2‐cyclopentanediol and cis ‐ and trans ‐1,2‐cyclohexanediol. In the gas phase, the stereospecific ion‐molecule reaction gives characteristic ions and substantial differences are observed in their relative abundances from which the diastereoisomers of those cyclic glycols can be clearly differentiated. Copyright © 2000 John Wiley & Sons, Ltd.