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Employing target modifications for the investigation of liquid infrared matrix‐assisted laser desorption/ionization mass spectrometry
Author(s) -
Cramer R.,
Burlingame A. L.
Publication year - 2000
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(20000130)14:2<53::aid-rcm833>3.0.co;2-h
Subject(s) - chemistry , mass spectrometry , desorption , matrix assisted laser desorption/ionization , ionization , analytical chemistry (journal) , infrared , chromatography , laser , maldi imaging , matrix assisted laser desorption electrospray ionization , matrix (chemical analysis) , sample preparation , ion source , ion , resolution (logic) , organic chemistry , adsorption , optics , physics , artificial intelligence , computer science
We present a new target modification for commercial ion sources to facilitate the use of liquid matrices such as glycerol and lactic acid in infrared matrix‐assisted laser desorption/ionization (IR‐MALDI). Benefits of this modification include increased sensitivity compared with the unmodified commercial target, mass resolution comparable to the best achievable with conventional IR‐MALDI or UV‐MALDI, and decreased sample volatility leading to an analysis time extended up to fivefold compared with using conventional target designs (up to 1 hour using volumes of only 250 nL). Copyright © 2000 John Wiley & Sons, Ltd.