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New ultraviolet signal actuated switching valve for the measurement of low level impurities by liquid chromatography/mass spectrometry
Author(s) -
Wolff JeanClaude,
Barr Lorna,
Moss Phillip
Publication year - 1999
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19991215)13:23<2376::aid-rcm801>3.0.co;2-9
Subject(s) - chemistry , mass spectrometry , ultraviolet , impurity , signal (programming language) , analytical chemistry (journal) , chromatography , matrix (chemical analysis) , spectrometer , detection limit , ion source , ion , optoelectronics , optics , organic chemistry , physics , computer science , programming language
A new ultraviolet (UV) signal actuated switching valve for diverting the main matrix compound to waste, preventing it entering the ion source of the mass spectrometer is described. Sensitivity for trace impurities eluting after the drug substance cimetidine or related compounds could be enhanced by a factor of 4–5. The increase in sensitivity was dependent on the type of ion source which interfaced the mass spectrometer. The benefit of the switching valve was greater with a line of sight type source than with an orthogonal one. The detection limit for a trace compound in a matrix compound was improved by up to a factor of 10 with the line of sight type source but only by a factor of 5 with the orthogonal source. Copyright © 1999 John Wiley & Sons, Ltd.