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Extracting and visualizing matrix‐assisted laser desorption/ionization time‐of‐flight mass spectral fingerprints
Author(s) -
Jarman Kristin H.,
Daly Don S.,
Petersen Catherine E.,
Saenz Adam J.,
Valentine Nancy B.,
Wahl Karen L.
Publication year - 1999
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19990815)13:15<1586::aid-rcm680>3.0.co;2-2
Subject(s) - chemistry , analyte , fingerprint (computing) , mass spectrometry , ionization , time of flight mass spectrometry , analytical chemistry (journal) , mass spectrum , matrix (chemical analysis) , time of flight , matrix assisted laser desorption/ionization , chromatography , desorption , artificial intelligence , ion , computer science , organic chemistry , adsorption
We have developed a method for constructing and extracting matrix‐assisted laser desorption/ionization (MALDI) fingerprints. This method is fully automated and statistically based, allowing a large number of spectra to be analyzed at a time in an objective manner. This method can be used to extract the fingerprint of a particular analyte from a spectrum containing multiple analytes. Therefore, this method lends itself well to real‐world applications where samples to be analyzed are likely to be impure. We illustrate this method on experimental results from a series of studies of E. coli and B. atrophaeus MALDI time‐of‐flight mass spectrometry (TOFMS) fingerprints. Copyright © 1999 John Wiley & Sons, Ltd.