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ConFlo III – an interface for high precision δ 13 C and δ 15 N analysis with an extended dynamic range
Author(s) -
Werner Roland A.,
Bruch Beate A.,
Brand Willi A.
Publication year - 1999
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19990715)13:13<1237::aid-rcm633>3.0.co;2-c
Subject(s) - chemistry , analytical chemistry (journal) , analyser , isotope dilution , carbon 13 , dilution , isotope ratio mass spectrometry , range (aeronautics) , dynamic range , mass spectrometry , chromatography , nuclear physics , optics , thermodynamics , physics , materials science , composite material
A newly developed interface coupling a CHN combustion device (elemental analyser ‘EA’) to an isotope ratio mass spectrometer is described and evaluated. The purpose of the device is to extend the dynamic range of δ 13 C and δ 15 N analysis from less than 2 orders of magnitude to more than 3 orders of magnitude. Carbon isotope ratio measurements of atropine as a model compound have been performed analysing between 1 µg to 5 mg C with acceptable to excellent precision (0.6 to 0.06‰, δ‐notation). The correction due to the blank signal is critical for sample amounts smaller than 4 µg C. The maximum sample weight is determined by the combustion capacity of the EA. Larger sample amounts are measured using dilution of a small part of the EA effluent with helium. The dilution mechanism works virtually free of isotope fractionation. Copyright © 1999 John Wiley & Sons, Ltd.