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Copper and iron interactions with angiotensin‐converting enzyme inhibitors. A study by fast‐atom bombardment tandem mass spectrometry
Author(s) -
Silva Cristina M. L.,
Duarte M. Filomena,
Mira M. Lourdes,
Florêncio M. Helena,
Versluis Kees,
Heck Albert J. R.
Publication year - 1999
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19990630)13:12<1098::aid-rcm618>3.0.co;2-y
Subject(s) - chemistry , enalaprilat , fast atom bombardment , lisinopril , captopril , mass spectrometry , metal , tandem mass spectrometry , nickel , tandem , angiotensin converting enzyme , chromatography , ace inhibitor , organic chemistry , medicine , blood pressure , radiology , materials science , composite material
Fast atom bombardment, combined with high‐energy collision‐induced tandem mass spectrometry, has been used to investigate gas‐phase metal‐ion interactions with captopril, enalaprilat and lisinopril, all angiotensin‐converting enzyme inhibitors.Suggestions for the location of metal‐binding sites are presented. For captopril, metal binding occurs most likely at both the sulphur and the nitrogen atom. For enalaprilat and lisinopril, binding preferably occurs at the amine nitrogen. Copyright © 1999 John Wiley & Sons, Ltd.