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Selected ion flow tube mass spectrometry of urine headspace
Author(s) -
Smith David,
Španěl Patrik,
Holland Tracey A.,
Al Singari Waleed,
Elder James B.
Publication year - 1999
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19990430)13:8<724::aid-rcm548>3.0.co;2-e
Subject(s) - chemistry , urine , chromatography , ammonia , mass spectrometry , acetone , methanol , nitric acid , nitric oxide , inorganic chemistry , biochemistry , organic chemistry
We describe the use of our selected ion flow tube mass spectrometric technique (SIFT‐MS) for the analysis of the headspace above urine. Ammonia, nitric oxide, acetone, ethanol and methanol are identified as the dominant species. As expected, the ammonia is increased in the headspace by making the urine alkaline and the nitric oxide is increased by making the urine acidic. Nitric oxide is abnormally high in the headspace of acidified bacterially infected urine and nitrous acid is also detected. The potential clinical implications of analyses of urine by SIFT‐MS are alluded to. Copyright © 1999 John Wiley & Sons, Ltd.