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Automated strategies for obtaining standardized collisionally induced dissociation spectra on a benchtop ion trap mass spectrometer
Author(s) -
Lopez Linda L.,
Tiller Philip R.,
Senko Michael W.,
Schwartz Jae C.
Publication year - 1999
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19990430)13:8<663::aid-rcm538>3.0.co;2-h
Subject(s) - chemistry , quadrupole ion trap , fragmentation (computing) , ion trap , mass spectrometry , ion , mass spectrum , dissociation (chemistry) , hybrid mass spectrometer , analytical chemistry (journal) , quadrupole , collision induced dissociation , spectral line , spectrometer , quadrupole mass analyzer , mass , triple quadrupole mass spectrometer , selected reaction monitoring , tandem mass spectrometry , chromatography , atomic physics , physics , organic chemistry , astronomy , quantum mechanics , computer science , operating system
An automated method for obtaining standardized collisionally induced dissociation (CID) spectra using two novel ion activation techniques on a quadrupole ion trap mass spectrometer is described. This strategy simultaneously produces optimal CID spectra “on‐the‐fly” and maximizes the amount of structurally specific fragment ions obtained in a single experiment, thus eliminating the need for individual tuning of specific mass‐to‐charge ratios and permitting fragmentation conditions to be more consistently reproduced. Copyright © 1999 John Wiley & Sons, Ltd.