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An improved method for the measurement of the angiotensin‐converting enzyme inhibitor lisinopril in human plasma by stable isotope dilution gas chromatography/negative ion chemical ionization mass spectrometry
Author(s) -
Leis H. J.,
Fauler G.,
Raspotnig G.,
Windischhofer W.
Publication year - 1999
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19990430)13:8<650::aid-rcm536>3.0.co;2-x
Subject(s) - chemistry , chromatography , derivatization , isotope dilution , lisinopril , mass spectrometry , chemical ionization , gas chromatography , solid phase extraction , gas chromatography–mass spectrometry , extraction (chemistry) , sorbent , angiotensin converting enzyme , ion , ionization , organic chemistry , medicine , radiology , blood pressure , adsorption
An improved method for the quantitative measurement of the angiotensin‐converting enzyme inhibitor lisinopril in human plasma is presented. The assay is based on gas chromatography/negative ion chemical ionization mass spectrometry. The method involves solid phase extraction on C18 sorbent and derivatization to the pentafluorobenzyl diester trifluoroacetamide derivatives. Copyright © 1999 John Wiley & Sons, Ltd.