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Quantitative analysis of pethidine using liquid secondary ion and tandem mass spectrometry
Author(s) -
Song Fengrui,
Cui Meng,
Liu Shuying
Publication year - 1999
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19990330)13:6<478::aid-rcm509>3.0.co;2-e
Subject(s) - chemistry , tandem mass spectrometry , chromatography , mass spectrometry , liquid chromatography–mass spectrometry , selected reaction monitoring , quantitative analysis (chemistry) , analytical chemistry (journal)
A method for the quantatitive determination of pethidine in human urine by liquid secondary ion and tandem mass spectrometry is presented. Quantification was carried out by using ketamine as internal standard. It was found that the collision‐induced dissociation (CID) spectrum of the [M + H] + ion of pethidine exhibited a prominent daughter ion at m/z 220 and ketamine also yielded the same daughter ion at m/z 220. For ((quadrupole)) quantitative analysis, the first quadrupole mass filter was set to transmit m/z 220 and a narrow‐range magnet scan yielded a spectrum of parents, including m/z 238 and 248, correspending to ketamine and pethidine, respectively. Copyright © 1999 John Wiley & Sons, Ltd.