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Simultaneous determination of dimethylarsinic acid and monomethylarsonic acid after derivatization with thioglycol methylate by gas chromatography/mass spectrometry
Author(s) -
Mester Zoltán,
Horváth Gyula,
Vitányi György,
Lelik László,
Fodor Péter
Publication year - 1999
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19990315)13:5<350::aid-rcm490>3.0.co;2-v
Subject(s) - chemistry , derivatization , chromatography , mass spectrometry , gas chromatography–mass spectrometry , gas chromatography , detection limit , fragmentation (computing) , arsenobetaine , yield (engineering) , arsenic , organic chemistry , inductively coupled plasma mass spectrometry , computer science , metallurgy , operating system , materials science
A gas chromatography/mass spectrometry (GC/MS) method has been developed to determine two methylated arsenic species in human urine samples. The yield of derivatization for dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA) using thioglycol methylate (TGM) was measured. The detection limit for the derivatized DMA and MMA using the GC/MS method are 0.95 and 0.8 ng cm −3 , respectively. This simple and rapid method has good precision and accuracy. Fragmentation routes of derivatized MMA and DMA are suggested on accurate mass measurements. Copyright © 1999 John Wiley & Sons, Ltd.