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Accurate mass determinations for the confirmation and identification of organic microcontaminants in surface water using on‐line solid‐phase extraction liquid chromatography electrospray orthogonal‐acceleration time‐of‐flight mass spectrometry
Author(s) -
Hogenboom A. C.,
Niessen W. M. A.,
Little D.,
Brinkman U. A. Th.
Publication year - 1999
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19990130)13:2<125::aid-rcm473>3.0.co;2-s
Subject(s) - chemistry , mass spectrometry , chromatography , electrospray , time of flight mass spectrometry , solid phase extraction , liquid chromatography–mass spectrometry , tandem mass spectrometry , analytical chemistry (journal) , electrospray ionization , extraction (chemistry) , ionization , organic chemistry , ion
The identification of polar microcontaminants in surface water is an important issue in environmental analysis. Liquid chromatography/mass spectrometry (LC/MS) is frequently applied for this purpose. However, even in combination with tandem mass spectrometry (MS/MS), unambiguous identification of the compounds detected is often difficult. The potential of an alternative strategy, based on the ability of an orthogonal‐acceleration time‐of‐flight mass spectrometer to routinely perform accurate mass determination at 10 ppm in on‐line LC/MS, is explored. On‐line solid‐phase extraction LC electrospray orthogonal‐acceleration time‐of‐flight mass spectrometry is shown to enable the determination of pesticides from various compound classes in surface water in the concentration range of 0.1 to 10 µg/L. In addition, the ability to discriminate and unambiguously identify pesticides in mixtures of isobaric and/or isomeric compounds is investigated. Copyright © 1999 John Wiley & Sons, Ltd.