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The possibility of the direct measurement of micelle weight by electrospray ionization mass spectrometry
Author(s) -
Nohara Daisuke,
Ohkoshi Takashi,
Sakai Tomoya
Publication year - 1998
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19981215)12:23<1933::aid-rcm410>3.0.co;2-n
Subject(s) - chemistry , micelle , electrospray ionization , mass spectrometry , electrospray , analytical chemistry (journal) , dissolution , ionization , molecule , chromatography , molar mass distribution , bromide , ion , organic chemistry , polymer , aqueous solution
Measurement of the molecular weight of micelles, which are characteristic aggregates of molecules, was conducted using electrospray ionization mass spectrometry (ESI‐MS). Micelle solutions were prepared by dissolving octyltrimethylammonium bromide [OTAB: C 8 H 17 N(CH 3 ) 3 Br] in water alone, without other additives. From the measurement of the m/z of the doubly or triply charged ions, it was revealed that the micelle of OTAB exhibited an almost symmetrical and polydisperse distribution about the mean molecular weight of 5000–5500. This molecular weight information is in good accordance with other estimated values. This result demonstrated the possibility of a direct measurement of micelle weight by mass spectrometry. Copyright © 1998 John Wiley & Sons, Ltd.