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Electrospray mass spectrometry of angiotensin‐converting enzyme inhibitors
Author(s) -
Florêncio M. Helena,
Fernandez M. Tereza,
Mira M. Lurdes,
Millar Allan,
Jennings Keith R.
Publication year - 1998
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19981215)12:23<1928::aid-rcm405>3.0.co;2-w
Subject(s) - chemistry , fragmentation (computing) , electrospray , mass spectrometry , electrospray ionization , lisinopril , enalaprilat , ion , tandem mass spectrometry , chromatography , collision induced dissociation , captopril , analytical chemistry (journal) , angiotensin converting enzyme , ace inhibitor , organic chemistry , medicine , radiology , computer science , blood pressure , operating system
Electrospray ionisation (ESI) mass spectrometry combined with collision‐induced decomposition of ions given by captopril, lisinopril and enalaprilat, angiotensin‐converting enzyme (ACE) inhibitors, has been used to characterise these compounds. As expected, the ESI mass spectra are characterised by the presence of abundant [M + H] + ions with very little fragmentation at low cone voltages. Fragment ions are produced by collision‐induced decomposition of these ions at higher cone voltages, and in MS/MS experiments. Fragmentation pathways and structures of fragment ions observed have been proposed. Copyright © 1998 John Wiley & Sons, Ltd.