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Negative ion electrospray ionization tandem mass spectrometry in the structural characterization of penicillins
Author(s) -
Rabbolini Susanna,
Verardo Elisabetta,
Da Col Marco,
Gioacchini Anna Maria,
Traldi Pietro
Publication year - 1998
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19981130)12:22<1820::aid-rcm387>3.0.co;2-c
Subject(s) - chemistry , fragmentation (computing) , tandem mass spectrometry , electrospray ionization , electrospray , ion , mass spectrometry , top down proteomics , yield (engineering) , ion trap , tandem , analytical chemistry (journal) , chromatography , ring (chemistry) , selected reaction monitoring , organic chemistry , materials science , computer science , metallurgy , composite material , operating system
The mass spectrometry (MS) behaviour of ten commercially available penicillins has been studied by means of electrospray and multiple‐stage MS/MS experiments performed using an ion trap instrument. For all the examined compounds negative ions are produced under ESI conditions, with a yield two or three orders of magnitude higher than that observed for positive ions. MS n experiments indicate the occurrence of a fragmentation pathway related to the β‐lactam ring, different from that usually described for positive ions of these compounds, and provide structural information on both the β‐lactam ring and the side chains.© 1998 John Wiley & Sons, Ltd.