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Automated identification of isotopically labeled pesticides and metabolites by intelligent ‘real time’ liquid chromatography tandem mass spectrometry using a bench‐top ion trap mass spectrometer
Author(s) -
Drexler Dieter M.,
Tiller Philip R.,
Wilbert Sibylle M.,
Bramble Frederick Q.,
Schwartz Jae C.
Publication year - 1998
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19981030)12:20<1501::aid-rcm355>3.0.co;2-w
Subject(s) - chemistry , ion trap , mass spectrometry , chromatography , tandem mass spectrometry , selected reaction monitoring , analytical chemistry (journal) , liquid chromatography–mass spectrometry , ion , quadrupole ion trap , organic chemistry
A screening method was developed to specifically detect and identify isotopically labeled compounds automatically in real‐time using a HPLC/ion trap mass spectrometer utilizing newly developed isotopic pattern recognition software. The ion trap mass spectrometer specifically detected isotopically labeled compounds in complex matrices based on isotopic pattern recognition utilizing full scan MS and full scan MS/MS. The resultant data included MS and MS/MS structural information for each detected compound containing the appropriate isotopic response, which was to be used for structural confirmation. © 1998 John Wiley & Sons, Ltd.