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A new scan mode for the identification of multiply charged ions
Author(s) -
Thomson Bruce A.,
Chernushevich Igor V.
Publication year - 1998
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19981015)12:19<1323::aid-rcm344>3.0.co;2-t
Subject(s) - chemistry , ion , tandem mass spectrometry , tandem , quadrupole , mass spectrometry , triple quadrupole mass spectrometer , hybrid mass spectrometer , analytical chemistry (journal) , selected reaction monitoring , atomic physics , chromatography , physics , organic chemistry , materials science , composite material
A new scan mode is demonstrated for the identification of the presence of multiply charged ions in a mixture which contains singly charged background ions. This scan mode can be used to identify candidates for MS/MS in a complex mixture of ions, where multiply charged peptide ions are preferred for obtaining sequence information. In contrast with the conventional precursor ion scan mode, the new scan mode is more sensitive and provides a more general screening tool in the selection of candidate peptide and protein ions for MS/MS. It can be applied with triple‐quadrupole and quadrupole/time‐of‐flight tandem mass spectrometers. © 1998 John Wiley & Sons, Ltd.