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Mass spectrometric studies of tetrasubstituted 3a,4,5,11‐tetrahydro‐3 H ‐1,2,4‐triazolo[4,3‐ d ][1,5]benzothiazepines
Author(s) -
Xu Jiaxi,
He Meiyu,
Jin Sheng
Publication year - 1998
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19980831)12:16<1115::aid-rcm278>3.0.co;2-e
Subject(s) - chemistry , benzothiazole , electron ionization , mass spectrometry , ion , ring (chemistry) , conjugated system , molecule , medicinal chemistry , yield (engineering) , phenanthridine , ionization , photochemistry , computational chemistry , stereochemistry , organic chemistry , polymer , materials science , chromatography , metallurgy
Abstract The mass spectrometric behaviour of seven tetrasubstituted 3a,4,5,11‐tetrahydro‐3 H ‐1,2,4‐triazolo[4,3‐ d ][1,5]benzothiazepines has been studied with the aid of mass‐analysed ion kinetic energy spectrometry and exact mass measurements under electron impact ionization. All compounds show a tendency to eliminate a neutral substituted or unsubstituted styrene molecule from the thiazepine ring to yield 1,2,4‐triazolo[4,3‐ b ][1,3]benzothiazole ions, and further undergo reverse 1,3‐dipolar cycloadditions to give benzothiazole ions. The formation of stable conjugated fused tetracyclic systems, substituted 1,2,4‐triazolo[4,3‐ f ]phenanthridine ions, under electron impact ionization, has also been found. © 1998 John Wiley & Sons, Ltd.