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The b 1 ion derived from methionine is a stable species
Author(s) -
Tu YaPing,
Harrison Alex. G.
Publication year - 1998
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19980715)12:13<849::aid-rcm237>3.0.co;2-w
Subject(s) - chemistry , methionine , ion , fragmentation (computing) , dissociation (chemistry) , collision induced dissociation , medicinal chemistry , stereochemistry , amino acid , mass spectrometry , organic chemistry , chromatography , tandem mass spectrometry , biochemistry , computer science , operating system
Unimolecular fragmentation of the MH + ions of a number of methionine derivatives such as H‐Met‐OMe, H‐Met‐β‐naphthylamide, H‐Met‐Gly‐OH, H‐Met‐Ala‐OH and H‐Met‐Phe‐OH results in formation of the methionine b 1 ion ( m/z 132) in significant yields. Since α‐aminoacylium ions are generally unstable and not observed, it is proposed that the stable form of the b 1 ion from these methionine derivatives is methyl‐cationated α‐amino‐γ‐thiobutyrolactone. Under low‐energy collision‐induced dissociation conditions this b 1 ion readily loses CO to form the a 1 ion, CH 3 SCH 2 CH 2 CH=NH 2 + . © 1998 John Wiley & Sons, Ltd.