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On‐line mass spectrometry: real‐time monitoring and kinetics analysis for the photolysis of idoxifene
Author(s) -
Brum Jeffrey,
Dell’Orco Philip
Publication year - 1998
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19980615)12:11<741::aid-rcm224>3.0.co;2-4
Subject(s) - chemistry , photodissociation , mass spectrometry , ionization , atmospheric pressure , electrospray ionization , ion , chemical ionization , kinetics , selected reaction monitoring , analytical chemistry (journal) , atmospheric pressure chemical ionization , methanol , photochemistry , chromatography , tandem mass spectrometry , organic chemistry , meteorology , quantum mechanics , physics
We report on our initial investigations utilizing unmodified atmospheric pressure ionization interfaces for real‐time monitoring of liquid phase reactions. As a model reaction we have investigated the photolysis of a substituted triphenylethylene molecule (SB 223030)in methanol monitored with both nebulized assisted electrospray and atmospheric pressure chemical ionization in positive ion mode. The approach allows the monitoring of the parent species and five relevant reaction products simultaneously. The quality of the kinetic data is illustrated by modeling the reaction system using pseudo‐first order approximations. In this particular study the signal available from extracted ion data of the relevant [M+H] + ions is directly used in the model without adjustment, thus demonstrating the potential utility of such MS interfaces for in situ probing. Future applications are discussed. © 1998 John Wiley & Sons, Ltd.