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First application of thermal vapor deposition method to matrix‐assisted laser desorption ionization mass spectrometry: determination of molecular mass of bis ( p ‐methyl benzylidene) sorbitol
Author(s) -
Kim Sung H.,
Shin Chul M.,
Yoo Jong S.
Publication year - 1998
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19980615)12:11<701::aid-rcm223>3.0.co;2-b
Subject(s) - chemistry , mass spectrometry , sorbitol , thermal desorption , analytical chemistry (journal) , thermal decomposition , chromatography , desorption , sample preparation in mass spectrometry , ferulic acid , ionization , matrix (chemical analysis) , matrix assisted laser desorption/ionization , sample preparation , surface enhanced laser desorption/ionization , organic chemistry , electrospray ionization , adsorption , ion
A thermal vapor deposition method for crystallization of insoluble analytes with matrix is established as a new sample preparation method for Matrix‐assisted laser desorption/ionization mass spectrometry (MALDI‐MS). A mixture of mono, bis and tris ( p ‐methyl benzylidene) sorbitols was incorporated into microcrystals of ferulic acid, which was confirmed by confocal micrographs. Molecular masses of sorbitol derivatives were determined in this way by MALDI‐MS without thermal decomposition. © 1998 John Wiley & Sons, Ltd.