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Sequential mass spectrometry and MS n analyses of combinatorial libraries by using automated matrix‐assisted laser desorption/ionization Fourier transform mass spectrometry
Author(s) -
Tutko Diane C.,
Henry Kent D.,
Winger Brian E.,
Stout Howard,
Hemling Mark
Publication year - 1998
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19980331)12:6<335::aid-rcm160>3.0.co;2-t
Subject(s) - fourier transform ion cyclotron resonance , chemistry , mass spectrometry , analytical chemistry (journal) , fourier transform , ionization , ion , ion cyclotron resonance , matrix (chemical analysis) , top down proteomics , maldi imaging , protein mass spectrometry , matrix assisted laser desorption/ionization , desorption , electrospray ionization , chromatography , cyclotron , physics , organic chemistry , quantum mechanics , adsorption
This note demonstrates that accurate mass and MS/MS data can be rapidly and easily obtained using an automated matrix‐assisted laser desorption/ionization Fourier transform MS procedure for multiple samples. Multiple ionization techniques were used simultaneously in order to introduce sample and mass reference ions into the Fourier transform ion cyclotron resonance cell. In this way 20 samples from a combinatorial library were analyzed automatically in one hour, with RMS errors of less than 5 ppm for the masses of both parent and fragment ions. © 1998 John Wiley & Sons, Ltd.