Premium
An eluent–jet interface for chemical ionization mass spectrometry and coupling of microcolumn liquid chromatography with electron ionization mass spectrometry
Author(s) -
Dijkstra Reyer J.,
Van Baar Ben L. M.,
Kientz Charles E.,
Niessen Wilfried M. A.,
Brinkman Udo A. Th.
Publication year - 1998
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19980115)12:1<5::aid-rcm109>3.0.co;2-2
Subject(s) - chemistry , mass spectrometry , chromatography , analytical chemistry (journal) , chemical ionization , ionization , direct electron ionization liquid chromatography–mass spectrometry interface , electron ionization , column chromatography , atmospheric pressure chemical ionization , ion , organic chemistry
An improved eluent–jet interface was used to combine flow‐injection analysis (FIA) and micro‐column liquid chromatography (LC) on‐line with mass spectrometry (MS) in the electron ionization (EI) and solvent‐independent chemical ionization (CI) modes. Good results were obtained for a series of pesticides and for 2‐(diethylamino)ethanol (DEAE), a precursor of the chemical warfare V‐agents. When using single‐ion monitoring, 50 pg of DEAE could be detected in the CI mode, and a linear calibration plot was obtained in the test range of 50–1000 pg. EI‐MS spectra obtained in both FIA and micro‐LC experiments were closely analogous to those in conventional mass spectral libraries. © 1998 John Wiley & Sons, Ltd.