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The use of liquid chromatography combined with a quadrupole time‐of‐flight analyser for the identification of trace impurities in drug substance
Author(s) -
Eckers Christine,
Haskins Neville,
Langridge James
Publication year - 1997
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(199711)11:17<1916::aid-rcm96>3.0.co;2-8
Subject(s) - analyser , chemistry , quadrupole time of flight , mass spectrometry , impurity , chromatography , time of flight , quadrupole , triple quadrupole mass spectrometer , quadrupole mass analyzer , hybrid mass spectrometer , analytical chemistry (journal) , time of flight mass spectrometry , spectrometer , trace (psycholinguistics) , ion , selected reaction monitoring , tandem mass spectrometry , organic chemistry , optics , physics , atomic physics , ionization , linguistics , philosophy
This paper shows the use of a quadrupole time‐of‐flight mass spectrometer combined with a liquid chromatograph for the identification of trace impurities in a drug substance. LC/MS/MS data obtained on trace impurities using this instrument compare favourably with those previously obtained on triple quadrupole mass spectrometers and in addition the high resoltuion capabilities of the ToF analyser allow accurate mass measurement of the fragment ions to better than 5 ppm in most cases. © 1997 John Wiley & Sons, Ltd.