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An Investigation into the Importance of Polymer–Matrix Miscibility Using Surfactant Modified Matrix‐assisted Laser Desorption/Ionization Mass Spectrometry
Author(s) -
Kassis Camille M.,
DeSimone Joseph M.,
Linton Richard W.,
Lange Gary W.,
Friedman Robert M.
Publication year - 1997
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19970830)11:13<1462::aid-rcm44>3.0.co;2-2
Subject(s) - chemistry , miscibility , mass spectrometry , polymer , matrix assisted laser desorption/ionization , desorption , matrix (chemical analysis) , sample preparation , analyte , analytical chemistry (journal) , methyl methacrylate , chromatography , soft laser desorption , copolymer , organic chemistry , adsorption
Sample preparation, namely finding a suitable matrix–analyte combination, has been one of the most important concerns in using matrix‐assisted laser desorption/ionization mass spectrometry (MALDI‐MS) for synthetic polymers. Herein we report the novel use of surfactants in the polymer sample preparation procedure. Specifically, three nonionic surfactants were investigated for MALDI analysis of poly(methyl methacrylate) (PMMA). This approach resulted in major enhancements in the PMMA molecular ion signals with dithranol as the matrix. The results illustrate the importance of polymer–matrix miscibility in optimizing MALDI investigations. © 1997 John Wiley & Sons, Ltd.