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Electron Impact Mass Spectra of Substituted 1‐Aryl‐2‐arylsulphonylamino‐1,4,5,6‐tetrahydropyrimidines
Author(s) -
Ovcharenko Vladimir,
Szacon Elzbieta,
Tkaczynski Tadeusz,
Matosiuk Dariusz,
Pihlaja Kalevi
Publication year - 1997
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19970830)11:13<1407::aid-rcm21>3.0.co;2-q
Subject(s) - chemistry , fragmentation (computing) , aryl , electron ionization , mass spectrum , pyrimidine , dissociation (chemistry) , ion , spectral line , collision induced dissociation , medicinal chemistry , mass spectrometry , computational chemistry , stereochemistry , organic chemistry , tandem mass spectrometry , alkyl , physics , chromatography , astronomy , computer science , ionization , operating system
Fragmentation pathways of the title compounds were studied using accurate mass measurements and collision‐induced dissociation spectra. Substituents in the ortho position of the aryl group at the pyrimidine ring were found to play a special role in the electron impact (EI) induced fragmentation of these structures. The fragmentation pathways involving various pyrimidine ring cleavages are compared to those of the analogous five‐membered heterocycles, 1‐aryl‐2‐arylsulphonylamino‐2‐imidazolines. Discussion of the CID spectra is focused on the dissociation channels characteristic of the differently substituted cyclic arylguanidium ions [M−SO 2 Ar] + which give rise to the base peaks in the EI spectra of the pyrimidine derivatives studied. © 1997 John Wiley & Sons, Ltd.