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Linkage determination of alditol disaccharides using high‐energy collision‐induced dissociation spectra of sodium cationized molecules
Author(s) -
Kováčik Vladimír,
Hirsch Ján,
Heerma Wigger
Publication year - 1997
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(199708)11:12<1353::aid-rcm987>3.0.co;2-9
Subject(s) - chemistry , molecule , mass spectrum , dissociation (chemistry) , deuterium , protonation , ethylene glycol , collision induced dissociation , ion , methanol , mass spectrometry , organic chemistry , chromatography , tandem mass spectrometry , physics , quantum mechanics
Oligosaccharide alditols containing a deuterium atom at the alditol C‐1 position can be used to obtain information about the masses and linkages of the various residues. The high‐energy collision‐induced dissociation (CID) spectra of the protonated compounds show mainly glycosidic bond cleavage with charge retention on the alditol containing Y‐type ions. The CID spectra of the sodium‐cationized compounds show additional fragment ions resulting from cross‐ring cleavages. Moreover the elimination of methanol, formaldehyde and ethylene glycol molecules, as deuterium labelled or unlabelled species, appeared to provide a reliable criterion to determine the linkage positions at the alditol unit. © 1997 John Wiley & Sons, Ltd.