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Mass‐selected reagent ion chemical ionization and multiple tandem mass spectrometry techniques in an ion trap mass spectrometer for structural analysis
Author(s) -
Sharifi Mayran,
Einhorn Jacques
Publication year - 1997
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(199707)11:11<1185::aid-rcm890>3.0.co;2-v
Subject(s) - chemistry , mass spectrometry , ion trap , reagent , tandem mass spectrometry , chemical ionization , ion , quadrupole ion trap , selected reaction monitoring , ion source , polyatomic ion , analytical chemistry (journal) , ionization , organic chemistry , chromatography
Mass‐selected reagent ion chemical ionization (CI) performed in an ion trap instrument is an efficient tool to investigate gas‐phase ion reactivities and therefore to find out new and/or optimized applications for structural analysis. For instance, it was shown that the C 3 H 6 O + . (58 mass units) molecular ion originated from vinyl methyl ether (VME) should necessarily be used alone (i.e. unit‐mass selected) to produce significant diagnostic‐ions for double bond location in aliphatic alkenes. Regarding the assignment of epoxides, the previous NO + /CI method was adapted for an optimal use in the trap through isolation of NO + cation from N 2 O (instead of NO) plasma and production of the acylium diagnostic‐ions via CID of [M − H] + formed by NO + ‐induced hydride abstraction. New alkylation ion‐products, e.g. RCH = O + ‐al , were also found to characterize isomeric epoxides as a result of either an initial electrophilic addition of the C 2 H 5 + cation (with saturated epoxides) or a methyl‐transfer from [VME] + . (with α,β‐unsaturated epoxides). The multiple tandem mass spectrometry (MS n ) capabilities of the ion trap were essential to achieve reagent ion mass‐selection, structural assignment of the diagnostic‐ions, or to provide further selectivity. © 1997 John Wiley & Sons, Ltd.