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Chiral Recognition Via Host–Guest Interactions Detected by Fast‐atom Bombardment Mass Spectrometry: Principles and Limitations
Author(s) -
Dobó A.,
Lipták M.,
Huszthy P.,
Vékey K.
Publication year - 1997
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(199705)11:8<889::aid-rcm911>3.0.co;2-i
Subject(s) - chemistry , fast atom bombardment , mass spectrometry , atom (system on chip) , reproducibility , ion , intensity (physics) , function (biology) , analytical chemistry (journal) , computational chemistry , chromatography , organic chemistry , computer science , biology , embedded system , physics , quantum mechanics , evolutionary biology
An intensity function combining peak intensities in the same manner as that in which equilibrium constants combine ion activities is suggested for chracterization of enantioselectivity by fast‐atom bombardment mass spectrometry. The intensity function combined with the use of two internal standards, one similar to the host, one to the guest compounds is shown to give excellent results: The enantioselectivity is better by up to factor of 10 than that obtained using one internal standard only, and its reproducibility is ca . a factor of 10 better, than that obtained using relative peak intensitities (the RPI method). © 1997 John Wiley & Sons, Ltd.