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Liquid Chromatography/Electrospray Tandem Mass Spectrometry of Methylated Purine Bases
Author(s) -
Catinella Silvia,
Rovatti Luca,
Hamdan Mahmoud,
Porcelli Brunetta,
Frosi Barbara,
Marinello Enrico
Publication year - 1997
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(199705)11:8<869::aid-rcm923>3.0.co;2-d
Subject(s) - chemistry , chromatography , electrospray , mass spectrometry , tandem mass spectrometry , electrospray mass spectrometry , liquid chromatography–mass spectrometry , tandem , protein mass spectrometry , purine , sample preparation in mass spectrometry , electrospray ionization , organic chemistry , enzyme , materials science , composite material
Aqueous solutions containing synthetic mixtures of model methylated purine bases have been examined by liquid chromatography/electrospray tandem mass spectrometry. Efficient chromatographic separation together with characteristic fragment ions derived from selected parent molecular ions allowed fast and reliable identification of the individual components within the investigated mixtures including some isomeric structures. Some of the deductions in the present work regarding the chromatography and mass spectrometry can be easily extended to analysis which may involve biofluids containing members of this class of compounds. © 1997 John Wiley & Sons, Ltd.