Premium
Observation of Varying Molecular Weight Distributions in Matrix‐assisted Laser Desorption/Ionization Time‐of‐Flight Analysis of Polymethyl Methacrylate
Author(s) -
Guo Baochuan,
Chen H.,
Rashidzadeh H.,
Liu X.
Publication year - 1997
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19970422)11:7<781::aid-rcm915>3.0.co;2-t
Subject(s) - polymethyl methacrylate , chemistry , desorption , matrix assisted laser desorption/ionization , molar mass distribution , ionization , polymer , analytical chemistry (journal) , matrix (chemical analysis) , time of flight mass spectrometry , sample preparation , molecular mass , mass spectrometry , chromatography , organic chemistry , ion , enzyme , adsorption
The molecular weight distribution of a polymethyl methacrylate (PMMA 4K) standard was subjected to matrix‐assisted laser desorption/ionization time‐of‐flight (MALDI‐TOF_ mass spectrometric analysis. It was observed that the molecular weight distribution measured by MALDI‐TOF could vary by as much as 27% even with a nearly same set of experimental parameters, and that this variation was due to mass discrimination against larger PMMA oligomers. Results indicate that the observed mass discrimination resulted mainly from the MALDI sample preparation and that a systematic study of the effects of sample preparation of MALDI‐TOF analysis of polymers is needed to minimize potential mass discrimination. A brief explanation for the mass discrimination is also given. © 1997 John Wiley & Sons, Ltd.