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Characterization of Toxaphene by High Resolution Gas Chromatography Combined with High Resolution Mass Spectrometry and Tandem Mass Spectrometry
Author(s) -
Santos F. J.,
Galceran M. T.,
Caixach J.,
Rivera J.,
Huguet X.
Publication year - 1997
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19970228)11:4<341::aid-rcm832>3.0.co;2-n
Subject(s) - chemistry , mass spectrometry , electron ionization , analytical chemistry (journal) , chromatography , gas chromatography , resolution (logic) , tandem mass spectrometry , fragmentation (computing) , isobutane , toxaphene , ion , ionization , organic chemistry , artificial intelligence , pesticide , computer science , agronomy , catalysis , biology , operating system , biochemistry
We examined the use of high resolution gas chromatography‐electron ionization high resolution mass spectrometry (HRGC/EI‐HRMS) in determining the toxaphene homologue distribution. Operating parameters such as electron energy, trap current and source temperature were optimized in order to obtain the maximum signal of the [M–C] + and [M–HCl] +• fragment ions of each homologue group. Internal interferences due to the fragment ions from the homologues with one and two additional chlorine atoms were eliminated using EI‐HRMS at a resolving power of 10 000 or higher. Tandem mass spectrometry (EI‐MS/MS) was used in the fragmentation studies. HRGC/EI‐HRMS‐selected ion monitoring (SIM) at a resolving power of 10 000 was used to determine the homologue distribution of a commercial toxaphene mixture. This technique gave detection limits of ppb level. The performance of HRGC/EI‐HRMS‐SIM was compared to HRGC/ECNI‐MS using isobutane as a moderating gas. © 1997 John Wiley & Sons, Ltd.