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Formation of Radical Anion Adduct between Paclitaxel and Matrix under Fast‐atom Bombardment
Author(s) -
Madhusudanan K. P.
Publication year - 1997
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19970215)11:3<295::aid-rcm816>3.0.co;2-8
Subject(s) - chemistry , adduct , fast atom bombardment , deprotonation , ion , decomposition , medicinal chemistry , matrix (chemical analysis) , photochemistry , organic chemistry , chromatography
The effect of different matrices on the negative‐ion fast‐atom bombardment mass spectrum of Paclitaxel has been studied. It is found that the nitro‐containing matrices, such as 3‐nitrobenzyl alcohol, give rise to abundant radical anion adducts. Collision‐induced decomposition of these adducts leads to the formation of deprotonated Paclitaxel and the matrix molecular anions. © 1997 John Wiley & Sons, Ltd.