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Determination of the Mitins, Sulcofuron and Flucofuron, Using Liquid Chromatography Combined with Negative‐ion Electrospray Ionization Mass Spectrometry†
Author(s) -
Hancock P. M.,
White S. J. G.,
Catlow D. A.,
Baugh P. J.,
Bonwick G. A.,
Davies D. H.
Publication year - 1997
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19970131)11:2<195::aid-rcm745>3.0.co;2-g
Subject(s) - chemistry , chromatography , electrospray ionization , analyte , selected reaction monitoring , mass spectrometry , electrospray , detection limit , direct electron ionization liquid chromatography–mass spectrometry interface , analytical chemistry (journal) , selected ion monitoring , extractive electrospray ionization , liquid chromatography–mass spectrometry , chemical ionization , ionization , ion , sample preparation in mass spectrometry , tandem mass spectrometry , gas chromatography–mass spectrometry , organic chemistry
Flucofuron and sulcofuron, both examples of mitins, have been employed as the active ingredients in mothproofing formulations for the protection of textile fabrics by the dyeing industry. Monitoring of their presence in components of the river ecosystem is a regulatory requirement so that sensitive detection techniques are required to obtain valid data concerning the levels of target pollutants present. Several methods have previously been reported for their determination but most of these methods are either inefficient or meet with some difficulty when dealing with trace residues in environmental matrices. This study has focused on the development of a highly sensitive and specific method of detection for these analytes, employing liquid chromatography combined with negative‐ion electrospray ionization mass spectrometry operated in multiple‐reaction monitoring (MRM) mode. Linearity was observed for both analytes (2.5–2500pg) with correlation coefficients of 0.999 obtained routinely. The absolute instrumental limits of detection in MRM mode, defined as a signal‐to‐noise ratio of 3:1, were calculated to be 2.5pg and 10pg for flucofuron and sulcofuron, respectively. © 1997 John Wiley & Sons, Ltd.