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Enhanced Cationization of Polymers Using Delayed Ion Extraction with Matrix‐assisted Laser Desorption/Ionization
Author(s) -
Mowat Ian A.,
Donovan Robert J.,
Maier Robert R. J.
Publication year - 1997
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19970115)11:1<89::aid-rcm810>3.0.co;2-g
Subject(s) - chemistry , polymer , ionization , fragmentation (computing) , desorption , matrix assisted laser desorption/ionization , field desorption , ion , laser , analytical chemistry (journal) , soft laser desorption , extraction (chemistry) , mass spectrometry , monomer , matrix (chemical analysis) , electric field , matrix assisted laser desorption electrospray ionization , chromatography , electron ionization , organic chemistry , optics , adsorption , physics , computer science , operating system , quantum mechanics
Cation attachment during matrix‐assisted laser desorption/ionization (MALDI) of various synthetic polymers was investigated. The ions were created in a field‐free source and extracted by a pulsed electric field applied at a known and variable time delay after the laser pulse. This is shown to increase the magnitude of the cationized polymer signal obtained, and also allows higher laser intensities to be used to induce fragmentation in the polymer. Additional structural information is thus provided about the monomers and end groups that is not available from measurements solely of the mass distribution of the intact cationized polymer. Delayed extraction can also provide important information about the timescale of the cation attachment processes occurring during MALDI. © 1997 John Wiley & Sons, Ltd.