Premium
A New Derivatization Reaction for the Identification and Determination of Organic Acids by Positive‐ion Electrospray Mass Spectrometry
Author(s) -
Bartók T.,
Komoróczy R.,
Börcsök G.,
Sági F.,
Hegyes P.,
Bartók M.
Publication year - 1997
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19970115)11:1<133::aid-rcm804>3.0.co;2-0
Subject(s) - chemistry , derivatization , electrospray ionization , mass spectrometry , chromatography , electrospray , detection limit , electrospray mass spectrometry , selected reaction monitoring , ion , selected ion monitoring , analytical chemistry (journal) , gas chromatography–mass spectrometry , tandem mass spectrometry , organic chemistry
A new derivatization reaction was developed for the characterization of organic acids by electrospray ionization mass spectrometry in the highly sensitive positive‐ion mode, using N,N ′‐dicyclohexylcarbodimide and N,N ′‐dimethylethylenediamine. Suitability of the reaction was demonstrated on different types of organic acids. When selected‐ion monitoring was applied, the detection limit was at the low femtomol level. © 1997 John Wiley & Sons, Ltd.