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Studies on the Selection of New Matrices for Ultraviolet Matrix‐assisted Laser Desorption/Ionization Time‐of‐flight Mass Spectrometry
Author(s) -
Krause Joern,
Stoeckli Markus,
Schlunegger Urs Peter
Publication year - 1996
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(199612)10:15<1927::aid-rcm709>3.0.co;2-v
Subject(s) - chemistry , intramolecular force , mass spectrometry , desorption , ultraviolet , matrix (chemical analysis) , ionization , matrix assisted laser desorption/ionization , analytical chemistry (journal) , chromatography , organic chemistry , ion , physics , quantum mechanics , adsorption
A new group of compounds has been successfully tested as matrices for ultraviolet matrix‐assisted laser desorption/ionization mass spectrometry (UV‐MALDI MS). Several new matrices for UV‐MALDI MS have been found by choosing, as potential matrices, compounds that perform an intramolecular proton transfer along an intramolecular H‐bond under UV irradiation. Compounds of this type are, for example, salicylamide, salicylanilide, several ortho ‐hydroxyacetophenones and ortho ‐hydroxybenzophenones. The matrix activity of these compounds is compared to the corresponding meta ‐ and para ‐isomers and to the matrix activity of such well known matrices as 2,5‐dihydroxybenzoic acid and 2,4,6‐trihydroxyacetophenone. It was found that meta ‐ and para ‐substituted hydroxycarbonyl compounds show either a significantly lower or no matrix activity compared with the ortho isomers.