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High Throughput Electrospray Mass Spectrometry of Combinatorial Chemistry Racks with Automated Contamination Surveillance and Results Reporting
Author(s) -
Hegy G.,
Görlach E.,
Richmond R.,
Bitsch F.
Publication year - 1996
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(199612)10:15<1894::aid-rcm708>3.0.co;2-2
Subject(s) - chemistry , mass spectrometry , sample (material) , contamination , throughput , electrospray ionization , electrospray , analytical chemistry (journal) , extractive electrospray ionization , chromatography , process engineering , sample preparation in mass spectrometry , computer science , ecology , telecommunications , engineering , wireless , biology
An automated high throughput, flow injection analysis electrospray ionization and atmospheric pressure chemical ionization mass spectroscopy system was developed to cope with the measurement of thousands of combinatorial chemistry samples per month. This system employs the 96‐well Micronic sample rack as the basic sample handling unit. The entire analytical process encompasses automated input of sample information, set up of mass spectrometer analysis parameters, expected compound checking and subsequent reporting to the customers. Strong emphasis was placed on the design of automated contamination surveillance and results reporting. A visual interface program was written in‐house to facilitate customer viewing of their results via the Sandoz network