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Chemical End‐group Derivatization of Poly(ethyleneglycol)—Investigation by Matrix‐assisted Laser Desorption/Ionization Mass Spectrometry
Author(s) -
Weidner St.,
Kühn G.
Publication year - 1996
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(19960610)10:8<942::aid-rcm599>3.0.co;2-k
Subject(s) - chemistry , derivatization , mass spectrometry , polymer , matrix assisted laser desorption/ionization , desorption , chemical ionization , end group , ionization , matrix (chemical analysis) , chromatography , organic chemistry , polymerization , ion , adsorption
The hydroxy end‐groups of poly(ethyleneglycol) polymers (PEG 1000 and 4000) were derivatized by etherification using methyl, ethyl and triphenylmethyl (trityl) halogenides. During the derivatization the molecular mass distribution of mono‐ and disubstituted polymers as well as unsubstituted polymers could be obtained by means of matrix‐assisted laser desorption/ionization mass spectrometry (MALDI/MS). For the first time MALDI/MS was used to investigate the kinetics of a chemical reaction involving synthetic polymers.