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Mass Spectral Study of Etoposide
Author(s) -
Vairamani M.,
Suma K.,
Kamal A.,
Gayatri N. L.
Publication year - 1996
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/(sici)1097-0231(199605)10:7<817::aid-rcm562>3.0.co;2-5
Subject(s) - chemistry , fragmentation (computing) , mass spectrum , collision induced dissociation , electron ionization , mass spectrometry , ion , chemical ionization , dissociation (chemistry) , analytical chemistry (journal) , ionization , computational chemistry , chromatography , tandem mass spectrometry , organic chemistry , computer science , operating system
The antitumour agent etoposide has been studied under electron impact, chemical ionization and liquid secondary ion mass spectral conditions. The major fragment ions are found to be due to the cleavage of C 4 –O, C 4 O–glycoside and C 1 –C′ 1 bonds. These fragmentation pathways are established by collision‐induced dissociation and accurate mass measurement. Mass spectral studies of 4′‐demethylepipodophyllotoxin, epipodophyllotoxin and their respective p ‐fluoroanilidine derivatives were also carried out.