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Female gamete segregation in two carriers of translocations involving 2q and 14q
Author(s) -
Escudero Tomás,
Lee Michael,
Sandalinas Mireia,
Munné Santiago
Publication year - 2000
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/(sici)1097-0223(200003)20:3<235::aid-pd791>3.0.co;2-1
Subject(s) - chromosomal translocation , gamete , genetics , biology , gynecology , medicine , sperm , gene
FISH, using a combination of whole‐chromosome painting and telomeric probes, was used to study the gamete segregation of two female carriers of translocations involving the same chromosome arms, 2q and 14q. Preimplantation genetic diagnosis of the first polar bodies of these oocytes permitted selecting normal embryos for replacement. Copyright © 2000 John Wiley & Sons, Ltd.