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Molecular cytogenetic characterization of a prenatally detected supernumerary minute marker chromosome 8
Author(s) -
Starke Heike,
Schreyer Isolde,
Kähler Christine,
Fiedler Wolfgang,
Beensen Volkmar,
Heller Anita,
Nietzel Angela,
Claussen Uwe,
Liehr Thomas
Publication year - 1999
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/(sici)1097-0223(199912)19:12<1169::aid-pd731>3.0.co;2-v
Subject(s) - marker chromosome , small supernumerary marker chromosome , karyotype , fluorescence in situ hybridization , biology , supernumerary , chromosome , genetics , microbiology and biotechnology , cytogenetics , genetic marker , fish <actinopterygii> , gene , anatomy , fishery
The characterization of a prenatally detected very small (approximately half of 18p—(karyotype: 47,XX,+mar[16]/46,XX[7]) supernumerary marker chromosome (SMC) identified by GTG‐banding analysis is described. The marker has been identified as derived from chromosome 8 centromeric material using a combination of different cytogenetic (GTG‐, NOR‐, CBG banding), molecular cytogenetic (24 colour‐fluorescent in situ hybridization [FISH], three‐colour FISH using centromeric probes for all human chromosomes) and molecular genetic techniques (microsatellite analysis). This is the first case described with such a minute SMC derived from chromosome 8 diagnosed prenatally, the 15th case reporting on a SMC originating from chromosome 8 and the third such case without any severe clinical features. Copyright © 1999 John Wiley & Sons, Ltd.