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Multi‐system cytomegalovirus fetopathy by recurrent infection in a pregnant woman with hepatitis B
Author(s) -
Nigro Giovanni,
La Torre Renato,
Mazzocco Manuela,
Coacci Federica,
Riosa Barbara,
D'Emilio Claudia,
Cosmi Ermelando Vinicio
Publication year - 1999
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/(sici)1097-0223(199911)19:11<1070::aid-pd701>3.0.co;2-a
Subject(s) - medicine , cytomegalovirus , pregnancy , fetus , hepatitis b virus , obstetrics , immunology , abortion , avidity , hepatitis , gestation , virology , antibody , herpesviridae , virus , viral disease , biology , genetics
A pregnant woman with acute hepatitis B virus (HBV) infection had her second pregnancy terminated at 25 weeks' gestation because of fetal ascites and ventriculitis. Meconium peritonitis was also found at autopsy. No HBV DNA but cytomegalovirus (CMV) DNA was detected in the fetal liver and ascitic fluid. Recurrent maternal CMV infection was demonstrated by pre‐existing CMV IgG antibodies, high IgG avidity and low IgM levels. After abortion, the patient developed chronic active hepatitis. Nevertheless, having become pregnant again with a new partner, she had an uneventful third pregnancy and gave birth to a healthy boy. Copyright © 1999 John Wiley & Sons, Ltd.