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Prenatal diagnosis of congenital varicella syndrome and detection of varicella‐zoster virus in the fetus: a case report
Author(s) -
Hartung John,
Enders Gisela,
Chaoui Rabih,
Arents Annette,
Tennstedt Cornelia,
Bollmann Rainer
Publication year - 1999
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/(sici)1097-0223(199902)19:2<163::aid-pd483>3.0.co;2-9
Subject(s) - fetus , medicine , varicella zoster virus , aborted fetus , abortion , therapeutic abortion , prenatal diagnosis , amniotic fluid , gestation , polymerase chain reaction , virology , virus , obstetrics , pregnancy , pathology , biology , genetics , biochemistry , gene
Varicella syndrome (VS) specific malformations were sonographically seen at 22 weeks and 3 days of gestation. Fetal infection was demonstrated by detection of varicella‐zoster virus (VZV) DNA in fetal blood and amniotic fluid by polymerase chain reaction (PCR). Following therapeutic abortion, fetal infection was confirmed by detection of VZV DNA in several fetal tissues and placenta, and by histopathological findings like miliary calcified necroses in fetal organs. Copyright © 1999 John Wiley & Sons, Ltd.