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Preimplantation diagnosis of the aneuploidies most commonly found in spontaneous abortions and live births: XY, 13, 14, 15, 16, 18, 21, 22
Author(s) -
Munné Santiago,
Magli Cristina,
Bahçe Muhterem,
Fung Jingly,
Legator Mona,
Morrison Larry,
Cohert Jacques,
Gianaroli Luca
Publication year - 1998
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/(sici)1097-0223(199812)18:13<1459::aid-pd514>3.0.co;2-v
Subject(s) - obstetrics , aneuploidy , medicine , gynecology , live birth , prenatal diagnosis , pregnancy , biology , fetus , genetics , chromosome , gene
The present preimplantation diagnosis test is able to screen for the most common aneuploidies from single blastomeres in about five hours with a 15 per cent misdiagnosis. This means that the risk of spontaneous abortion and trisomic offspring for women of advanced maternal age could be reduced to the same level as younger women for whom prenatal diagnosis is usually not necessary. Better probes and more fluorochromes could improve the success rate of the test. Copyright © 1998 John Wiley & Sons, Ltd.