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Confined placental mosaicism for trisomy 8 and intra‐uterine growth retardation
Author(s) -
Saks Emily,
McCoy M. Cathleen,
Damron Joseph,
Kelly Thaddeus E.
Publication year - 1998
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/(sici)1097-0223(199811)18:11<1202::aid-pd425>3.0.co;2-q
Subject(s) - trisomy , aneuploidy , growth retardation , uniparental disomy , pregnancy , biology , placenta , obstetrics , fetal growth , karyotype , medicine , genetics , fetus , gynecology , chromosome , gene
This report describes a case of apparent confined placental mosaicism for trisomy 8 in a pregnancy which produced a male infant with intra‐uterine growth retardation. Postnatal cytogenetic and molecular studies were consistent with biparental disomy 8. Postnatally, the infant experienced a period of rapid catch‐up growth and exhibited no clinical features of trisomy 8 mosaicism. His development was age appropriate. Copyright © 1998 John Wiley & Sons, Ltd.