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Reversed end‐diastolic umbilical flow in a first‐trimester fetus with congenital heart disease
Author(s) -
Borrell Antoni,
Costa Dolors,
Martinez Josep M.,
Farre M. Teresa,
Palacio Montserrat,
Mortera Carlos,
Fortuny Albert
Publication year - 1998
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/(sici)1097-0223(1998100)18:10<1001::aid-pd395>3.0.co;2-v
Subject(s) - medicine , umbilical artery , fetus , pulmonary atresia , cardiology , heart disease , atresia , pulmonary artery , pregnancy , aneuploidy , biology , genetics , biochemistry , gene , chromosome
Reversed end‐diastolic umbilical artery velocities and a reduced chorionic sac were first seen at 10 weeks in a pregnancy subsequently showing a normal male karyotype on chorionic villi. Four weeks later Doppler studies demonstrated normal umbilical artery waveforms. At 20 weeks, ultrasound examination of the fetus revealed a mild pericardic effusion, hypoplastic right heart with hypertrophic myocardium and a single umbilical artery, suggesting pulmonary atresia. After neonatal death, pathological studies confirmed pulmonary atresia. This case suggests that reversed end‐diastolic umbilical flow in the first trimester may identify a subgroup of fetuses with a lethal abnormality (heart defect, severe intra‐uterine retardation, aneuploidy or others). Copyright © 1998 John Wiley & Sons, Ltd.