Premium
Schwangerschafts protein 1 (SP1) adds little to the age‐related detection of fetal Down syndrome in the first trimester of pregnancy
Author(s) -
Kornman L. H.,
Morssink L. P.,
Ten Hoor K. A.,
De Wolf B. T. H. M.,
Kloosterman M. D.,
Beekhuis J. R.,
Mantingh A.
Publication year - 1998
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/(sici)1097-0223(199810)18:10<1086::aid-pd393>3.0.co;2-8
Subject(s) - down syndrome , pregnancy , fetus , second trimester , medicine , obstetrics , first trimester , prenatal diagnosis , gynecology , biology , genetics , psychiatry
Schwangerschafts Protein 1 (SP1), being a placental protein appearing in the maternal circulation early in pregnancy, has been investigated as a potential marker for Down syndrome in the first trimester. Our study compared SP1 levels in 15 pregnancies with a Down syndrome fetus and 97 matched controls. Although the median MoM in Down syndrome pregnancies (0·49) was lower than in controls, its use as a marker added very little to the detection rate above the maternal age alone. Copyright © 1998 John Wiley & Sons, Ltd.