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Agreement between predicted risk and prevalence of Down syndrome in second‐trimester triple‐marker screening in Japan
Author(s) -
Onda Takekazu,
Tanaka Tadao,
Takeda Osamu,
Kitagawa Michihiro,
Kuwabara Yoshinori,
Yamamoto Hiroyuki,
Iinuma Kazuso,
Shimomura Katsunori
Publication year - 1998
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/(sici)1097-0223(199809)18:9<956::aid-pd370>3.0.co;2-r
Subject(s) - down syndrome , triple test , medicine , second trimester , prospective cohort study , obstetrics , pregnancy , pediatrics , fetus , biology , psychiatry , genetics
Based on 9350 pregnant Japanese women who were screened by serum triple‐marker determination, accuracy of predicted risk for Down syndrome was examined using 24 Down syndrome cases detected either prenatally or postnatally. The correlation is statistically very high ( r =0·98) between the predicted risks and the prevalence of Down syndrome cases. Here we emphasize that this could be accomplished only by an extensive follow‐up study, implemented in our prospective intervention programme. © 1998 John Wiley & Sons, Ltd.